Non-Obstructive Azoospermia
Azoospermic men with testicular failure (non-obstructive azoospermia) after a testis biopsy have either a sertoli cell-only pattern, maturation arrest, or hypo-spermatogenesis. In non-obstructive azoospermia, the testes are abnormal, atrophic, or absent, and consequently the sperm production is severely disturbed to absent.
The levels of follicle-stimulating hormone (FSH) tend to elevate (hyper-gonadotropic) when the feedback loop is interrupted. This condition is found in 49%–93% of men with azoospermia. High levels of FSH show only testicular failure, which includes absence or failure to produce, low production, and maturation arrest during the process of spermatogenesis.
The causes for testicular failure include congenital issues such as certain genetic conditions (e.g., Klinefelter Syndrome), cases of cryptorchidism or sertoli cell-only syndrome, as well as conditions acquired by infection (orchitis), surgery (trauma, cancer), radiation, or other causes.
Until recently, scientists assumed that men with non-obstructive azoospermia were untreatable. The only options for having children were to use donor spermatozoa, adoption, or TESE.
Azoospermia and Testosterone
Many cases of prolonged azoospermia are a result of killing all the spermatogonial stem cells inside the testis by infection or other reasons that we do not know. In other instances, however, the stem spermatogonia survive but fail to differentiate into sperm.
Our examination of the hormonal status of azoospermic cases revealed that the failure of the differentiation of spermatogonia could not be the result of insufficient stimulation by gonadotropins or testosterone. Follicle-stimulating hormone (FSH) levels were 1.5-fold normal and luteinizing hormone (LH) and testosterone levels remained unchanged.
Researchers have hypothesized that in azoospermia cases, testosterone might actually be inhibiting the spermatogonial differentiation. Many scientists have conducted numerous studies based on this hypothesis and researchers have suppressed testosterone by treating azoospermic rats with gonadotropin releasing hormone (GnRH) antagonists that prevented the blockage of spermatogonial differentiation. Although the spermatogonia differentiated, they could not progress past the round spermatid stage as long as the testosterone was suppressed.
We expected the testosterone to support normal spermatogenesis, but it appeared to inhibit this process in azoospermia conditions.
Therefore, we performed more studies to confirm that testosterone is inhibitory in azoospermia cases. We noted that testosterone action in normal spermatogenesis supports spermatocyte and spermatid development has only small quantitative effects on spermatogonia. So testosterone’s newly discovered inhibitory phenomenon is an extra action and does not replace its usual action.
SpermHope® Treatment
SpermHope® restores fertility temporary or permanently by slightly reducing testosterone levels, and this reduction in azoospermia patients removes the blockage from the spermatogonia stem cells and allowed them to be differentiated to advanced stages.
"The user's testosterone levels will stay in the normal range because this medication does not affect the body or the sex drive."
Conclusion
In azoospermia conditions, the testosterone inhibits the differentiation of the spermatogonia, whereas in normal spermatogenesis the testosterone supports the survival and differentiation of spermatocytes and spermatids.
We found a formula from natural sources that reduces the testosterone levels in human body to acceptable levels without any side-effects. This formula treats non-obstructive azoospermia.
Until recently, we assumed that non-obstructive azoospermia was untreatable. We then changed our method of non-obstructive azoospermia treatments and showed that SpermHope® can restore fertility by naturally reducing the testosterone level.
SpermHope® Can Help in Two Ways
First, SpermHope® increases a man’s sperm count so that sperm in the semen after previous being zero, and a partner can get pregnant naturally or by in vitro fertilization (IVF).
Second, if the semen does not contain any sperm, Testicular Sperm Extraction (TESE) can be performed. In this case, SpermHope® increases the chances of finding good sperm for Intracytoplasmic sperm injection (ICSI).
Before undergoing any surgical procedures, men should attempt to increase their chances of locating sperm in the TESE by taking SpermHope® treatments. Studies have shown that surgeries disturb functioning of the testis, which could become a long-term issue.
There are numerous male fertility products on the market, but SpermHope® is unique in that it is only used for azoospermia (Stages I and II). Although natural supplements can help many people, the results vary. We have worked hard to ensure that we have provided the best and most-effective products.
http://www.spermhope.com
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Fantastic blog! I like the post a lot! Very interesting and useful read. I'll be back in the future to check your posts. Thanks for sharing wonderful thoughts. Thumbs up!
ReplyDeleteAzoospermia Treatment
Azoospermia patients usually have high FSH levels, The high levels of FSH indicate that you have primary testicular failure. it's important to know that FSH is not the reason of your azoospermia (many still think that if we lowering FSH then we can fix the problem and this is absolutely wrong), it’s important to know that the high levels of FSH is result of the azoospermia. so lowering FSH by traditional treatments (HCG injection, Clomiphene or even natural herbs that increase testosterone) will not be useful in primary testicular failure.
ReplyDeletemost azoospermia cases is not curable, we can only improve the sperm production but can not restore to normal production.
Hello
ReplyDeleteI became pregnant after 10 yrs. My husband had Azoospermia so i was unable to get pregnant.
But after taking Ayurveda medicine his sperm count increased. I would like to share my story. I would like every one suffering from male infertility to know that Ayurveda medicine can help them.
Please visit my blog
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thanks
Which treatments
DeleteThanks to doctor Dr Obodo for taking me out of shame, I am almost 40 years of age but I couldn’t get married because I know could not impregnate a woman because I was suffering from AZOOSPERMIA (ZORO SPERM COUNT) and hospitals did their best for me but I still could not cure. So, Some months back I read about this doctor recommendation online and I decide to give it a try hence hospitals could not help, he administer his medication on me and after the treatment, behold for the first time in my life I started experiencing sperm. You too can be treated just like me and be cured. If interested you can reach him through: whatsapp (+2348155425481) (templeofanswer@hotmail . co . uk)
DeleteThanks to doctor Dr Obodo for taking me out of shame, I am almost 40 years of age but I couldn’t get married because I know could not impregnate a woman because I was suffering from AZOOSPERMIA (ZORO SPERM COUNT) and hospitals did their best for me but I still could not cure. So, Some months back I read about this doctor recommendation online and I decide to give it a try hence hospitals could not help, he administer his medication on me and after the treatment, behold for the first time in my life I started experiencing sperm. You too can be treated just like me and be cured. If interested you can reach him through: whatsapp (+2348155425481) (templeofanswer@hotmail . co . uk)
Dear Ellen,
ReplyDeleteYou are confusing the readers between low sperm count and azoospermia. It is not the same at all. Azoospermia mean zero sperm count all the time and there is different types of azoospermia.
Low sperm count more easy to fix be many different treatments that available a in the market.
Non-Obstructive Azoospermia with novel treatment
ReplyDeleteCase Description:
FSH: Normal level
LH: Normal level
Testosterone: Normal level
TESE Diagnosis: Testicular biopsies, right and left COMPLETE MATURATION ARREST
Microscopic Description
Microscope:
(A) Right testicular biopsy: There are approximately 462 seminiferous tubules. All are of average diameter but with slightly thickened lamina propria. All show decreased population of spematogonia, primary spermatocytes and spermatids.
Spermatid count 0-63 / tubule. 23.6% seminiferous tubule show no spermatid, 61.9% show less than 20 spermatids and 14.5% show 20 or more spermatids per seminiferous tubule. Sertoli cells and leydig cells are normal.
(B) Left testicular biopsy: There are approximately 704 sections of the seminiferous tubules. All are of average diameter but with slightly thickened lamina propria. All show decreased population of spematogonia, primary spermatocytes and spermatids.
Spermatid count 0-55 / tubule. 83.8% seminiferous tubule show no spermatid, 23.6% show less than 20 spermatids and 14.5% show 20 or more spermatids per seminiferous tubule. Sertoli cells and leydig cells are normal.
Treatment History:
The patient was diagnosed with azoospermia as no sperm were found even after multiple tests.
In 2011, his doctor prescribed Arimidex but no positive results then later shifted to Clomid but again no positive results.
In 2012, he did Testicular Sperm Extraction (TESE) operation but no sperm found.even that didn’t prove to be fruitful.
He live with healthy lifestyle, no alcohol, no smoking, no carbonated drinks, no junk foods,running and hitting the gym.
In 2013, his doctor prescribed SpermHope and he began the treatment, he started taking SpermHope last August 2013. After stage 2, all hormone levels went down a little bit but still within normal levels. Meanwhile, the clinic found improvements in his sperm count, motility and normality rate. He did sperm frozen for backup purposes.
In 2014, he and his wife decide to do the next step and go through In-Vitro Fertilization (IVF). The doctors extracted 4 mature eggs from his wife and inject them with fresh sperms through Intracytoplasmic Sperm Injection (ICSI).
All 4 resulted into high-grade blastocysts. Then when the timing was right, the doctors transferred one of the blastocysts to his wife. That was at the end of March 2014. Then in April 2014, she was found to be pregnant!
It has been a long journey for him and his wife but now they are happy with their baby girl!
Dr. Abuelhija
I am 28 years old and married. My semen report says zero sperm count. My FSH level report says 60 mIU/ml. And my biopsy report says zero sperm count in my testis. I don't want to use sperm from any donors (sperm Bank). And I think there should be a way of getting a child by my own. How can I?
DeletePlease contact me to: Dr.abuelhija@gmail.com
DeleteThis comment has been removed by a blog administrator.
ReplyDeleteThis comment has been removed by a blog administrator.
ReplyDeleteBut if total T is already low, then how does spermhope help ? Do you have any studies in peer-reviewed literture ?
ReplyDeleteYou can contact me at: info@spermhope.com
DeleteWe need more details
Hi Dr... in the above case, after the patient had no success in finding sperms after TESE and then using SpermHope, did you manage to find the usable sperm in his semen or via another TESE?
ReplyDeleteYes, this is actually the idea, to improve the testis function to find few sperm in semen or TESE. we have patients that perform TESE and micro TESE but after using the treatment they found viable sperm for ICSI.
Deleteit's important to know that the success rate can different from person to another and the success rate of the treatment are 23% sperm in semen and 25% sperm by biopsy. that's mean 52% no effect in other cases, this can be due to genetic problem, very low stem cell number....
you can learn more about everything by visiting the website: www.SpermHope.com
We provide azoospermia treatment with the help of Chinese traditional medicine
ReplyDeleteAzoospermia is the condition in which the males are not able to find the produce the sperm due to which they suffer from male infertility. In order to know more about it, you can go through our blog post.
ReplyDeleteFrom this blog post people will know all the details that is directly related to azoospermia treatment. So anyone from you want to know then click and read the full post.
ReplyDeleteAzoospermia is the really common problem in men nowadays. Men who wants to get rid of this but wants to know the full azoospermia treatment process then you need to watch this video.
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ReplyDeleteAzoospermia is the deficiency of sperms in the semen of a male, which is linked with very low levels of fertility or even sterility. Natural infertility treatment especially made to increase healthful sperm formation and improves a man’s chances of becoming a father. Read More http://azoospermia.in/
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ReplyDeleteThank you for these informations.
ReplyDeleteI have the case of azoospermic, my FSH is increasing higher.
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ReplyDeleteHey there, Thank you so much for posting such a helpful and awareness creating blog. It is so kind of you to post such knowledgeable blogs. It was really worth my time. I will definitely recommend my colleagues to read this blog. You should be appreciated for the kind of work your doing cause people like you play a vital role in our society. A special thanks to you for posting pictures of your kids, they can make anyone feel blissful.Being a surrogacy consultant I have also written blogs like Surrogacy in UK and many more. Please do find time to read it feel free to share your thoughts!
ReplyDeleteI battled with ZERO SPERM COUNT ( Azoospermia ) for years until 6 months ego, I told my father in-law my problem because everybody was asking questions why we hasn’t got any kids after 9 years of marriage. I couldn’t help it than to break the silence to my father in-law, he gave me doctor Uduehi’s contact and I contacted him without wasting time, after I applied his medications I started experiencing sperm, although it was little at the benign but after a shot while it became more than 16 million. My wife is 2 months pregnant as I speak. You too is not left out, reach him if interested through: uduehiherbalcare@gmail.com phone/WhatsaPP: +2347084878384
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ReplyDeleteI battled with ZERO SPERM COUNT ( Azoospermia ) for years until 6 months ego, I told my father in-law my problem because everybody was asking questions why we hasn't got any kids after 9 years of marriage. I couldn't help it than to break the silence to my father in-law, he gave me doctor Uduehi’s contact and I contacted him without wasting time, after I applied his medications I started experiencing sperm, although it was little at the benign but after a shot while it became more than 16 million. My wife is 2 months pregnant as I speak. You too is not left out, reach him now through: uduehiherbalcare@gmail.com phone/WhatsaPP: +2347084878384
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the Azoospermia is caused by infections of the testicles, prostate, or reproductive tract such as epididymitis/orchitis, prostatitis, and venereal diseases such as Chlamydia. These can cause a blockage in the small tubules of the epididymis or the ejaculatory duct.ok, Agbara Herbal Cleanser flushes out this Infection in The Body and increase the level of the sperm released ok and it will make ejaculation effective ok,,,,Agbara cleanser work in the bloodstream of human ok to flushed out any effection ok, just encourage your partner to always use Agbara Herbal Cleanser at all time 2times in a day. Via….. drcureherbalhome@gmail.com
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Thanks to doctor Uduehi for taking me out of shame, I am almost 40 years of age but I couldn’t get married because I know could not impregnate a woman because I was suffering from AZOOSPERMIA (ZORO SPERM COUNT) and hospitals did their best for me but I still could not cure. So, Some months back I read about this doctor recommendation online and I decide to give it a try hence hospitals could not help, he administer his medication on me and after the treatment, behold for the first time in my life I started experiencing sperm. You too can be treated just like me and be cured. If interested you can reach him through: (+2347084878384) (uduehiherbalcare@gmail.com)
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