Monday, December 17, 2012

Non-Obstructive Azoospermia

Azoospermic men with testicular failure (non-obstructive azoospermia) after a testis biopsy have either a sertoli cell-only pattern, maturation arrest, or hypo-spermatogenesis. In non-obstructive azoospermia, the testes are abnormal, atrophic, or absent, and consequently the sperm production is severely disturbed to absent.

The levels of follicle-stimulating hormone (FSH) tend to elevate (hyper-gonadotropic) when the feedback loop is interrupted. This condition is found in 49%–93% of men with azoospermia. High levels of FSH show only testicular failure, which includes absence or failure to produce, low production, and maturation arrest during the process of spermatogenesis.

The causes for testicular failure include congenital issues such as certain genetic conditions (e.g., Klinefelter Syndrome), cases of cryptorchidism or sertoli cell-only syndrome, as well as conditions acquired by infection (orchitis), surgery (trauma, cancer), radiation, or other causes.

Until recently, scientists assumed that men with non-obstructive azoospermia were untreatable. The only options for having children were to use donor spermatozoa, adoption, or TESE.

Azoospermia and Testosterone

Many cases of prolonged azoospermia are a result of killing all the spermatogonial stem cells inside the testis by infection or other reasons that we do not know. In other instances, however, the stem spermatogonia survive but fail to differentiate into sperm.

Our examination of the hormonal status of azoospermic cases revealed that the failure of the differentiation of spermatogonia could not be the result of insufficient stimulation by gonadotropins or testosterone. Follicle-stimulating hormone (FSH) levels were 1.5-fold normal and luteinizing hormone (LH) and testosterone levels remained unchanged.

Researchers have hypothesized that in azoospermia cases, testosterone might actually be inhibiting the spermatogonial differentiation. Many scientists have conducted numerous studies based on this hypothesis and researchers have suppressed testosterone by treating azoospermic rats with gonadotropin releasing hormone (GnRH) antagonists that prevented the blockage of spermatogonial differentiation. Although the spermatogonia differentiated, they could not progress past the round spermatid stage as long as the testosterone was suppressed.

We expected the testosterone to support normal spermatogenesis, but it appeared to inhibit this process in azoospermia conditions.

Therefore, we performed more studies to confirm that testosterone is inhibitory in azoospermia cases. We noted that testosterone action in normal spermatogenesis supports spermatocyte and spermatid development has only small quantitative effects on spermatogonia. So testosterone’s newly discovered inhibitory phenomenon is an extra action and does not replace its usual action.

SpermHope® Treatment

SpermHope® restores fertility temporary or permanently by slightly reducing testosterone levels, and this reduction in azoospermia patients removes the blockage from the spermatogonia stem cells and allowed them to be differentiated to advanced stages.

"The user's testosterone levels will stay in the normal range because this medication does not affect the body or the sex drive."


In azoospermia conditions, the testosterone inhibits the differentiation of the spermatogonia, whereas in normal spermatogenesis the testosterone supports the survival and differentiation of spermatocytes and spermatids.

We found a formula from natural sources that reduces the testosterone levels in human body to acceptable levels without any side-effects. This formula treats non-obstructive azoospermia.

Until recently, we assumed that non-obstructive azoospermia was untreatable. We then changed our method of non-obstructive azoospermia treatments and showed that SpermHope® can restore fertility by naturally reducing the testosterone level.

SpermHope® Can Help in Two Ways

First, SpermHope® increases a man’s sperm count so that sperm in the semen after previous being zero, and a partner can get pregnant naturally or by in vitro fertilization (IVF).

Second, if the semen does not contain any sperm, Testicular Sperm Extraction (TESE) can be performed. In this case, SpermHope® increases the chances of finding good sperm for Intracytoplasmic sperm injection (ICSI).

Before undergoing any surgical procedures, men should attempt to increase their chances of locating sperm in the TESE by taking SpermHope® treatments. Studies have shown that surgeries disturb functioning of the testis, which could become a long-term issue.

There are numerous male fertility products on the market, but SpermHope® is unique in that it is only used for azoospermia (Stages I and II). Although natural supplements can help many people, the results vary. We have worked hard to ensure that we have provided the best and most-effective products.